The game is set between Resident Evil 4 and Resident Evil 5. It depicts the events shortly after the establishment of the Bioterrorism Security Assessment Alliance (BSAA), a counter-terrorism group introduced in Resident Evil 5. The story revolves around BSAA co-founders Jill Valentine and Chris Redfield, the protagonists of the first Resident Evil. During the game's events, Jill and Parker Luciani are sent to search for Chris Redfield and Jessica Sherawat on the SS Queen Zenobia, that serves as the game's setting. The game's story includes a flashback, which revolves around the "floating city" of Terragrigia (Italian for "Grey Earth") one year prior to the game's events, when the Federal Bioterrorism Commission (FBC) sent agents – including Parker and Jessica – to keep the situation under control after the bioterrorist organization "Il Veltro" launched an attack on the city using bio-organic weapons (BOW) in opposition to Terragrigia's solar energy development.
* Burn or mount
* Play the game